Genetic variants inTNFα,TGFB1, PTGS1andPTGS2genes are associated with diisocyanate-induced asthma
نویسندگان
چکیده
منابع مشابه
Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma.
Diisocyanates are the most common cause of occupational asthma, but risk factors are not well defined. A case-control study was conducted to investigate whether genetic variants in inflammatory response genes (TNFα, IL1α, IL1β, IL1RN, IL10, TGFB1, ADAM33, ALOX-5, PTGS1, PTGS2 and NAG-1/GDF15) are associated with increased susceptibility to diisocyanate asthma (DA). These genes were selected bas...
متن کاملGenetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced Asthma.
OBJECTIVE To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA). METHODS The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels. RESULTS The HLA-E rs15732...
متن کاملCTNNA3 (α-catenin) gene variants are associated with diisocyanate asthma: a replication study in a Caucasian worker population.
Recently, a genome-wide association study (GWAS) conducted in Korean subjects identified four CTNNA3 (alpha-T catenin) single nucleotide polymorphisms (SNPs) (rs10762058, rs7088181, rs1786929, and rs4378283) associated with diisocyanate-induced occupational asthma (DA). The CTNNA3 gene codes for a cadherin involved in formation of stretch-resistant cell-cell adhesions. We conducted a candidate ...
متن کاملGenetic variants on 17q21 are associated with asthma in a Han Chinese population.
A genome-wide study has shown an association between SNPs located on 17q21 and asthma. Such associations have been identified in several populations, but little is known about the Han Chinese population. We conducted a case-control study in a Han Chinese population to investigate the relationship between SNPs located on 17q21 and asthma; 241 asthmatic patients and 212 healthy controls were...
متن کاملHexamethylene Diisocyanate Asthma is Associated with Genetic Polymorphisms of CD14, IL-13, and IL-4RA
David I Bernstein, MD1, Grace E Kissling, PhD2, Gurgit Khurana Hershey, MD, PhD3, Berran Yucesoy, PhD4, Victor J Johnson, PhD4, André Cartier, MD5, Denyse Gautrin, PhD5, Joaquin Sastre, MD6, Louis-Philippe Boulet, MD7, Jean-Luc Malo, MD5, Santiago Quirce, MD6, Susan M Tarlo, MBBS8, Stacy Langmeyer, MS1, Michael I Luster, PhD4, and Zana L Lummus, PhD1 1University of Cincinnati College of Medicin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Immunotoxicology
سال: 2015
ISSN: 1547-691X,1547-6901
DOI: 10.3109/1547691x.2015.1017061